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Page 1
Loss of FoxOs in muscle increases strength and mitochondrial function during aging.
J Cachexia Sarcopenia Muscle. 2023 Feb;14(1):243-259. doi: 10.1002/jcsm.13124. Epub 2022 Nov 28.
J Cachexia Sarcopenia Muscle. 2023.
PMID: 36442857
Free PMC article.
Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle.
Bhardwaj G, Penniman CM, Jena J, Suarez Beltran PA, Foster C, Poro K, Junck TL, Hinton AO Jr, Souvenir R, Fuqua JD, Morales PE, Bravo-Sagua R, Sivitz WI, Lira VA, Abel ED, O'Neill BT.
Bhardwaj G, et al. Among authors: penniman cm.
J Clin Invest. 2021 Sep 15;131(18):e146415. doi: 10.1172/JCI146415.
J Clin Invest. 2021.
PMID: 34343133
Free PMC article.
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Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors.
Bhardwaj G, Penniman CM, Klaus K, Weatherford ET, Pan H, Dreyfuss JM, Nair KS, Kahn CR, O'Neill BT.
Bhardwaj G, et al. Among authors: penniman cm.
Front Physiol. 2022 Feb 4;12:779121. doi: 10.3389/fphys.2021.779121. eCollection 2021.
Front Physiol. 2022.
PMID: 35185597
Free PMC article.
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FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy.
O'Neill BT, Bhardwaj G, Penniman CM, Krumpoch MT, Suarez Beltran PA, Klaus K, Poro K, Li M, Pan H, Dreyfuss JM, Nair KS, Kahn CR.
O'Neill BT, et al. Among authors: penniman cm.
Diabetes. 2019 Mar;68(3):556-570. doi: 10.2337/db18-0416. Epub 2018 Dec 6.
Diabetes. 2019.
PMID: 30523026
Free PMC article.
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Elamipretide treatment during pregnancy ameliorates the progression of polycystic kidney disease in maternal and neonatal mice with PKD1 mutations.
Daneshgar N, Liang PI, Lan RS, Horstmann MM, Pack L, Bhardwaj G, Penniman CM, O'Neill BT, Dai DF.
Daneshgar N, et al. Among authors: penniman cm.
Kidney Int. 2022 May;101(5):906-911. doi: 10.1016/j.kint.2021.12.006. Epub 2021 Dec 22.
Kidney Int. 2022.
PMID: 34953771
Free PMC article.
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Loss of FoxOs in muscle reveals sex-based differences in insulin sensitivity but mitigates diet-induced obesity.
Penniman CM, Suarez Beltran PA, Bhardwaj G, Junck TL, Jena J, Poro K, Hirshman MF, Goodyear LJ, O'Neill BT.
Penniman CM, et al.
Mol Metab. 2019 Dec;30:203-220. doi: 10.1016/j.molmet.2019.10.001. Epub 2019 Oct 10.
Mol Metab. 2019.
PMID: 31767172
Free PMC article.
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Loss of iRhom2 accelerates fat gain and insulin resistance in diet-induced obesity despite reduced adipose tissue inflammation.
Skurski J, Penniman CM, Geesala R, Dixit G, Pulipati P, Bhardwaj G, Meyerholz DK, Issuree PD, O'Neill BT, Maretzky T.
Skurski J, et al. Among authors: penniman cm.
Metabolism. 2020 May;106:154194. doi: 10.1016/j.metabol.2020.154194. Epub 2020 Mar 2.
Metabolism. 2020.
PMID: 32135161
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